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SqlConnection conn = new SqlConnection(System.Configuration.ConfigurationSettings.AppSettings["conn"]);
SqlCommand comm = new SqlCommand("update tb1 set vName=@vName,iAge=@iAge where ID=@id", conn);

SqlParameter parm1 = new SqlParameter("@vName", SqlDbType.NVarChar, 50);
parm1.Value = ((TextBox)e.Item.FindControl("name")).Text;

SqlParameter parm2 = new SqlParameter("@iAge", SqlDbType.Int);
parm2.Value = ((TextBox)e.Item.FindControl("age")).Text;

SqlParameter parm3 = new SqlParameter("@id", SqlDbType.Int);
parm3.Value = this.DataGrid1.DataKeys[e.Item.ItemIndex];

comm.Parameters.Add(parm1);
comm.Parameters.Add(parm2);
comm.Parameters.Add(parm3);

conn.Open();
comm.ExecuteNonQuery();
conn.Close();